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	Teri Hatcher	Susan Mayer
	Felicity Huffman	Lynette Scavo
	Marcia Cross	Bree Van De Kamp
	Eva Longoria-Parker	Gabrielle Solis
	Jamie Denton	Mike Defino
	Nicolette Sheridan	Edie Britt
	Steven Culp	Rex Van De Kamp (2004-2005)
	Mark Moses	Paul Young
	Ricardo Chavira	Carlos Solis
	Cody Kasch	Zack Young
	Andrea Bowen	Julie Mayer
	Jesse Metcalfe	John
	Brenda Strong	Mary Alice Young
	Doug Savant	Tom Scavo
	Shane Kinsman	Porter Scavo
	Brent Kinsman	Preston Scavo
	Zane Huett	Parker Scavo
	Dylan Cline & Jordan Cline	Penny Scavo
	Shawn Pyfrom	Andrew Van De Kamp
	Joy Lauren	Danielle Van De Kamp
	Harriet Sansom Harris	Felicia Tilman  (2004-2005)
	Christine Estabrook	Martha Huber (2004)
	Richard Burgi	Karl Mayer
	Roger Bart	George Williams (2005)
	Alfre Woodard	Betty Applewhite (2005-2006)
	Mehcad Brooks	Matthew Applewhite (2005-2006)
	Nashawn Kearse	Caleb Applewhite (2005-2006)
	Joely Fisher	Nina Fletcher (2005-2006)
	Currie Graham	Ed Ferrera (2005-2006)